The question is, are there useful things that we can do with the results of a genome sequence that would bring benefit? And the answer is, today, should the majority of people go and have their genome sequenced? Probably not. But are there particular circumstances in which genome sequencing is really helpful? Yes, there are.

Each season was different and presented its own set of circumstances and challenges.

No matter the circumstances, just keep battling and keep battling.

I think you need to be able to adjust to the required circumstances and adjust your driving style.

It may be an extreme example brought about by abnormal circumstances - but the criteria of human rights kick in, surely, precisely when the conditions are extreme and the situation is abnormal.

There is no first-hand account of what the Queen was saying or thinking, so my job as an actor is to interpret her circumstances.

That's your goal every week: to put yourself in contention. There's a lot of circumstances and a lot of things that have to play out for that to happen.

A Scout smiles and whistles under all circumstances.

Being unemployed - or working at minimum wage - is rough in the best of circumstances.

I grew up in financially straitened circumstances and meat, which was expensive, was a rare thing at mealtimes. We ate meat about once a month, if that.

The way a play is seen is completely dependent on the circumstances and the world in which it is received.

Circumstances rule men; men do not rule circumstances.

I just had different circumstances than most players, and I think that has been an advantage - maybe I carry a little chip on my shoulder with just how tough it was for my parents to overcome some of those financial situations.

When I was 6, I learned where I came from, which was one step removed from the usual circumstances. I was adopted.

I have told friends and supporters who are urging me to run that I would not oppose President Johnson under any foreseeable circumstances.

In so far as such a theory is empirically correct it will also tell us what empirical facts it should be possible to observe in a given set of circumstances.

Americans of all backgrounds and in all kinds of circumstances are stressed out by feeling overwhelmed and being over-committed.

It's getting increasingly difficult to be a dreamer under any circumstances.

I think that what is truly unfortunate is when an entire party makes a decision that they're going to block every single thing that a president wants to accomplish. It's very - it's very hard to get anything done in those circumstances.

I grew up in a rural area. Books are what helped me transcend my circumstances.